Tuesday, July 24, 2018

Behavioral problems - which drugs to use? or not?

I went to a really great lecture (by Eric Hutchinson)  a week or so ago, and as a result today we are back to the topic of treating behavioral problems... using, as he describes it, a mechanistic approach.  So here are some questions for your perusal...
  1. What are some common abnormal behaviors in NHP? 
  2. If a basic behavior loop is stimulus -> internal processing -> behavior -> feedback, which of those steps can most be influenced by veterinary medicine alone (i.e. without behavioral management techniques)? Which can be influenced by behavioral management? 
  3. Barbering or hair pulling is a relatively common behavior in multiple species, including humans. 
    •     What is thought to be the primary physiologic mechanism, 
    •     What is the usual treatment, and 
    •     Why does it have a wide safety margin?
  4.    Benzodiazepines are sometimes suggested for treatment for behavioral problems 
    • How do benzodiazepines work in the brain? 
    • True or false: benzodiazepines are useful for a wide range of problem behaviors 
    • For what kind of conditions would they be appropriate to use? 
    • When should they never be used? 
      5. Self-injurious behavior
    1. What conditions of rearing predispose an animal to develop self-injurious behavior?
    2. What is thought to be the neurochemical deficit in self-injurious behavior?
      •  Which amino acid has proven useful in treating abnormal behaviors due to abnormal rearing? 
      • What category of drugs with a similar downstream mechanism to Q3 effects is often useful for self injurious behavior? 
      • Which member of this drug category takes up to a month to work, has off-target effects and has withdrawal effects? 
      • Which member of this drug category is not useful >8 weeks but has no withdrawal effects? 
    3. Which alpha 2A adrenergic agonist has proven useful in the most severe cases of self injurious behavior in NHP? 
      • What are some advantages of this drug? 
      • What are some disadvantages? 
    4. Which drug could you use occasionally prior to a known trigger for self injurious behavior to help prevent it? 
      6. General concept: What effect on behavior would you expect on withdrawing drug treatment therapy?
ANSWERS POSTED HERE

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