Monday, February 5, 2018

Q27: Spontaneous Diseases in Common Mouse Strains

image from clipartbarn
Why should you care?  Well, it's not unheard of for our investigators to suspect that pathology or behavior they discover is related to a mutation,  when in fact it's a feature of the background strain. 

So here is an eclectic collection of questions relating to our common inbred strains...

1. Which strain has long been used as a source of ES cells for targeted mutations and why is this a problem?

2. List 2 strains that have mutations in the dysferlin gene and what condition (s) results?

3. Which strain is known for has a high incidence of thymic T cell lymphoma and what is the genetic reason?  Which immunodeficient strain is also has a high incidence of T cell lymphoma?  Which strain has a high incidence of B cell lymphomas?

4. Which strain has a high incidence of cardiac abnormalities including epicardial mineralization and cardiomyopathy and is widely used for infectious disease studies?

5. Which 2 strains with high and low mammary tumor incidence (respectively) were developed from an A albino female to a DBA male?

6. Which strain historically had a very high incidence of mammary adenocarcinomas due to MMTV?

7. Which strain is known for its resistance to many infectious agents but susceptibility to mouse adenovirus 1 and encephalomyelitis?

8. Which induced disease  model is the DBA mouse known for and what is the human condition?

9. List 2 strains susceptible to seizures

10. List 2 strains that exhibit acallosity


ANSWERS ARE POSTED HERE