Fun fact Q 5: nonhuman primates models for malaria

Malaria Models

Aotus 

• What are the 2 hosts required for potentiation of malaria infections? (be specific)
• In general, can old world primates (OWM) be infected with human malaria spp. ? What about new world primates (NWM)?
• In general what procedure is necessary to establish a malaria model into a new NHP family?
• What is responsible for the recurrent fevers characteristic of clinical signs of malaria?
• In falciparum malaria, list the 3 different types of clinicopathology that can result in severe morbidity or death
• Which human malaria spp have a dormant stage in the liver, what are the dormant malaria forms called, and what is reactivation of dormant malaria called?
• Which human malaria species can cause severe glomerulonephrosis?  Which causes ARDS (acute respiratory disease syndrome)?
• Which malaria species are used to study blood stage malaria in the rhesus host?
• Which malaria species are considered to be the OWM analog of falciparum/vivax/malariae?
• Which is the most prevalent natural malaria species in OWM?
• What kind of malaria studies are NWM used for and why?
• Which NWM model (malaria spp, NWM spp) is the only one to reliably produce the dormant liver stage of malaria?
• Name the 2 spp of NWM malaria that are thought to be anthropozoonoses.  Which is most common in the wild?
• How is experimental malaria treated in NWM?  Is it curative?



Squirrel monkey: Saimiri b. boliviensis

• List the 2 types of model generally used for vaccine trials

Rhesus monkey Macaca mulatta