Q17: Coat Color Nomenclature

Picture: gengennews.com

It's time for some new questions, and this week I'm going to put up a few questions that test your knowledge of coat color nomenclature.  It's a confusing topic, and for many people (including me) it requires a number of iterations before it starts to sink in. So if you're thinking about studying for boards next year, it's never too soon to start thinking about it. Or if you just want to see if you can remember what you once knew... go right ahead!

I'm going to make it relatively easy for you on this first post...




 Considering the following...
A. Nonagouti locus,  a
B. Tyrosinase-related Protein 1 locus,  Tyrp
C. Tyrosinase locus,  Tyr

1. Which is responsible for:
- black/brown color?
- albinism
- agouti coat

2. Regarding the nonagouti gene,
- which is dominant, agouti or nonagouti?
- what is the banding pattern of colors along the hair for agouti?
- what are the colors and banding pattern in a cinnamon mouse?
- is a DBA mouse agouti?

3. Regarding nude mice (OK I know they don't have hair, I digress)
- What is the gene/allele symbol for a nude mouse?  Expand the gene symbol into words...
- What is the developmental abnormality that results in the immune deficiency in nude mice?
- Do they have normal B and NK cells?
- What happens to their immune deficiency as they age?

4. What color is this mouse?
- a/a Tyrp1b/Tyrp1b Tyrc/Tyrc  (please note the alleles should be superscripted, but I can't do that easily on here)

5. What color is this mouse?
- a+/a  Tyrp1B/ Tyrp1b   Tyr C/Tyrc

6. True or false?
- FVB and BALB/c (and other common albino mice) are albino because of a point mutation from a shared ancestor
- Mouse albinism is caused by disruption of the first step in the production of melanin
- The suppression of one gene by another is called epistasis.

7. Which of these gene/alleles are responsible for coat color dilution?
- Myo5a_d
- Mlph_ln
- Lyst_bg
- Kitl_sl
- Kit_W

8.  In Q7, what are the names of the dilution alleles?


Best of luck!  Will post the answers in a week...

Did you know? A group of flamingoes is a flamboyance