Q27: Spontaneous Diseases in Common Mouse Strains

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Why should you care?  Well, it's not unheard of for our investigators to suspect that pathology or behavior they discover is related to a mutation,  when in fact it's a feature of the background strain. 

So here is an eclectic collection of questions relating to our common inbred strains...

1. Which strain has long been used as a source of ES cells for targeted mutations and why is this a problem?

2. List 2 strains that have mutations in the dysferlin gene and what condition (s) results?

3. Which strain is known for has a high incidence of thymic T cell lymphoma and what is the genetic reason?  Which immunodeficient strain is also has a high incidence of T cell lymphoma?  Which strain has a high incidence of B cell lymphomas?

4. Which strain has a high incidence of cardiac abnormalities including epicardial mineralization and cardiomyopathy and is widely used for infectious disease studies?

5. Which 2 strains with high and low mammary tumor incidence (respectively) were developed from an A albino female to a DBA male?

6. Which strain historically had a very high incidence of mammary adenocarcinomas due to MMTV?

7. Which strain is known for its resistance to many infectious agents but susceptibility to mouse adenovirus 1 and encephalomyelitis?

8. Which induced disease  model is the DBA mouse known for and what is the human condition?

9. List 2 strains susceptible to seizures

10. List 2 strains that exhibit acallosity


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